Daniel Scott and Younsoo Bae
Block Copolymer Crosslinked Nanoassemblies Co-entrapping Hydrophobic Drugs and Lipophilic Polymer Additives
Block copolymer crosslinked nanoassemblies (CNAs) were synthesized to investigate their patterns of entrapping and releasing an anticancer drug (17-AAG) in the presence of a lipophilic polymer additive (polylactic acid: PLA) in the core. The CNAs were prepared by crosslinking poly (ethylene glycol)-poly (aspartate hydrazide) (PEG-Hyd) block copolymers through an amide bond. The CNAslocked in the particle size after co-entrapping 17-AAG and PLA (< 50 nm in diameter). PLA with various molecular weights (3.4, 6, and 7.5 kDa) was used as polymer additives that are small enough to diffuse into the CNA core.
English 
Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi