జర్నల్ ఆఫ్ పల్మనరీ మెడిసిన్

Incidence of Nasopharyngeal angiofibroma in Pakistan

Kalimullah Thahim

Abstract. Nasopharyngeal angiofibroma is a benign yet aggressive and destructive vascular lesion of head and neck tumor affecting predominately male between the age group of 15 to 20, also called Juvenile Nasopharyngeal angiofibroma. The present study is retrospective of surgically treated patients of juvenile nasopharyngeal angiofibroma. In this study we discuss major presenting complaints, correlation of radiological and intra operative methods along with the factors affecting the recurrence of juvenile nasopharyngeal angiofibroma. A study of 35 cases of juvenile angiofibroma was conducted from year 2000 to 2015 at Karachi, Pakistan, mostly male adolescent with age ranging from 15 to 20 years Introduction. Juvenile angiofibroma though rare yet an aggressive disease in view of excessive bleeding mainly occurring at puberty with predominantly male involvement. In Nasopharyngeal angiofibroma mass arise from nasopharynx close to sphenopalatine foramina accounts for 0.5 % of all head neck tumor. Material & Method. A retrospective study conducted on 35 patients at Civil Hospital and Park Lane Hospital Karachi during the year 2000 to 2015. In inclusion criteria, all patient diagnosed as angiofibroma with or without intracranial extension, while the exclusion criteria was considered in patients having bleeding disorder or unfit for surgery. Keywords: Androgen receptor, Benign tumor, Juvenile angiofibroma, embolization Result. The study was conducted in 35 patients, having age group between 12 to 22 years of age. Most of the patients (24 patients) fell in the age group between 15 to 17 years of age. Nasal obstruction was major complaint (35 patients) followed by epistaxis (26 patients). Few of them complaining of hyposmia and headache. However there were minor complaints such as facial swelling, hearing loss, trismus and nasal voice intonation. Majority of patients were without intracranial extension. Conclusion. JNA though rare, yet is prevalent in our setup. Facilities such as embolization have made the procedure easier and safer as compared to previous surgery, which conducted without embolization and required huge amount of blood transfusion. Surgical treatment still remained as gold standard treatment approach. Endoscopic treatment is gaining grounds in treatment option