Vladimir P Sheverdov, Maksim A Maryasov, Vera V Davydova, Oleg E Nasakin and Konstantin A Lyssenko
lMethyl 6-Amino-3-acyl-4-aryl-5-cyano-4H-pyran-2-carboxylates, 9-aryl-12-imino-10,11 dioxatricyclo-[5.3.2.01,6]-dodecan-7,8,8- tricarbonitriles, 2-R-1,2,5,6,7,8-hexahydroquinoline-3,3,4,4- tetra?arbonitriles were synthesized. The antiproliferative activity of obtained compounds was investigated. At a concentration of 10 μM test substances activity higher than that of the drug busulfan and cisplatin showed a compounds containing in its composition fragment of ethyl 1,1,2,2-tetracarbonitrile - 2-R-1,2,5,6,7,8- hexahydroquinoline-3,3,4,4-tetra?arbonitriles.
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