Mohammad Salehi, Wilrun Mittelstädt, Jens Packeisen, Markus Haase and Angela Hamann-Steinmeier
An Alternative Way to Prepare Biocompatible Nanotags with Increased Reproducibility of Results
Aggregation of nanoparticles (NP) occurs mostly during and after their biofunctionalization. Aggregations can lead to disfunction of the biomolecule which binds to NP like antibodies or enzymes. In many cases, disfunctions and the lack of reproducibility of the results are two major challenges during the use of nanotechnology. We demonstrate that the aggregation of nanoparticles can be controlled by choosing the optimal amount of crosslinker and furthermore the function of biomolecules can be protected by avoiding centrifugation steps. These investigations may provide a valuable guide in many other medical applications of nanostructures.
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