Structural biology is a branch of molecular biology, biochemistry, and biophysics which deals with the structure of biological macromolecules such as proteins and nucleic acids at molecular level and the mechanism behind their formation of structure. It also explains about that how the changes in the molecular structure of biological macromolecule can affect their function. It has been recently found that the endocytic sorting motif interactions are involved in Nef-mediated down modulation of mainly CD4 and CD3 receptors.
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