Darren Peters, Xuemei Luo, Ke Qiu and Ping Liang
Speeding Up Large-Scale Next Generation Sequencing Data Analysis with pBWA
Newly available DNA sequencing technologies can generate billions of DNA sequences in a single machine run, making it feasible to obtain an individual’s entire genome sequences very quickly and at a very affordable cost. These personal genome sequences can be used to identify genetic variations associated with variable traits, but they must first be aligned to a reference genome sequence using computer algorithms that make use of approximate string matching methods.
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